Review

New potential uses for cardiac troponins

Mayo Clinic & Mayo Medical School, Department of Internal Medicine, Division of Cardiovascular Diseases & Department of Laboratory Medicine & Pathology, Rochester, Minnesota, USA

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Allan S Jaffe

† Author for correspondence

Mayo Clinic & Mayo Medical School, Department of Internal Medicine, Division of Cardiovascular Diseases & Department of Laboratory Medicine & Pathology, Rochester, Minnesota, USA

Mayo Clinic, 200 First St. SW, Division of Cardiovascular Diseases, Gonda 5, Rochester, Minnesota 55905, USA.

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Email the corresponding author at jaffe.allan@mayo.edu

Published Online:17 Dec 2007https://doi.org/10.2217/17520363.1.4.491

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Abstract

This review briefly synthesizes the molecular biology of troponin, which is currently the best biochemical marker for the detection of cardiac injury and, thus, acute myocardial infarction as well. Potential new uses for the marker based on these insights, with a specific interest in cardiac troponin fragments that potentially could be linked to distinct clinical conditions, are described. Some of the clinical problems clinicians are faced with including how to use the markers in renal failure and the difficulties associated with the heterogeneity of current troponin assays are also discussed. Finally, we present the possibility of specific cardiac troponin fragments resulting from modification or degradation, associated with distinct pathological processes, as new potential uses for this biomarker.

Keywords:

Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.

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Vol. 1, No. 4

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Published online 17 December 2007

Published in print December 2007

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Financial & competing interests disclosure

Allan Jaffe is a consultant and has received research support from Dade-Behring and Beckman-Coulter. He is a consultant to Ortho Diagnostics and has consulted over time for most of the major diagnostic companies. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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