We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Journal of Comparative Effectiveness Research
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine
Review

Multifunctional cell-instructive materials for tissue regeneration

    J Kent Leach

    Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Drive, Davis, CA 95616, USA.

    Search for more papers by this author

    Email the corresponding author at jkleach@ucdavis.edu

    Published Online:18 Jul 2006https://doi.org/10.2217/17460751.1.4.447

    Abstract

    Current approaches in tissue engineering and regenerative medicine have focused on controlling the presentation of various factors that influence cellular behavior and tissue formation. Numerous biomaterials have been utilized as sites for new tissue growth by migrating or transplanted cells, nanoscale control of cellular behavior through the presentation of specific peptide sequences, and depots for growth factor release. More recently, the development of bioresponsive materials has emerged as a promising approach to cede control of temporal macromolecule presentation and material degradation to invading cell populations. Biomaterials now have the potential of possessing multiple functions in the process of tissue regeneration. This review summarizes some of the recent advances in the use of multifunctional biomaterials in the arena of tissue engineering. Specifically, the potential of various materials is described as it pertains to the control of cellular behavior, integration of engineered materials with host or transplanted tissue, and inductive factor presentation.

    Bibliography

    • 1  Langer R, Vacanti JP: Tissue engineering. Science260(5110), 920–926 (1993).Crossref, Medline, CAS, Google Scholar
    • 2  Alsberg E, Hill EE, Mooney DJ: Craniofacial tissue engineering. Crit. Rev. Oral Biol. Med.12(1), 64–75 (2001).Crossref, Medline, CAS, Google Scholar
    • 3  Danen EH, Sonnenberg A: Integrins in regulation of tissue development and function. J. Pathol.200(4), 471–480 (2003).Crossref, Medline, CAS, Google Scholar
    • 4  Stevens MM, George JH: Exploring and engineering the cell surface interface. Science310(5751), 1135–1138 (2005).Crossref, Medline, CAS, Google Scholar
    • 5  Lee KY, Mooney DJ: Hydrogels for tissue engineering. Chem. Rev.101(7), 1869–1880 (2001).Crossref, Medline, CAS, Google Scholar
    • 6  Drury JL, Mooney DJ: Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials24(24), 4337 (2003).Crossref, Medline, CAS, Google Scholar
    • 7  Kong HJ, Kaigler D, Kim K, Mooney DJ: Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution. Biomacromolecules5(5), 1720–1727 (2004).Crossref, Medline, CAS, Google Scholar
    • 8  Smetana K: Cell biology of hydrogels. Biomaterials14(14), 1046–1050 (1993).Crossref, Medline, CAS, Google Scholar
    • 9  Rowley JA, Mooney DJ: Alginate type and RGD density control myoblast phenotype. J. Biomed. Mater. Res.60(2), 217–223 (2002).Crossref, Medline, CAS, Google Scholar
    • 10  Benoit DSW, Anseth KS: The effect on osteoblast function of colocalized RGD and PHSRN epitopes on PEG surfaces. Biomaterials26(25), 5209–5220 (2005).Crossref, Medline, CAS, Google Scholar
    • 11  Hill E, Boontheekul T, Mooney DJ: Regulating activation of transplanted cells controls tissue regeneration. Proc. Natl Acad. Sci. USA103(8), 2494–2499 (2006).Crossref, Medline, CAS, Google Scholar
    • 12  Alsberg E, Anderson KW, Albeiruti A, Rowley JA, Mooney DJ: Engineering growing tissues. Proc. Natl Acad. Sci. USA99(19), 12025–12030 (2002).Crossref, Medline, CAS, Google Scholar
    • 13  Smith E, Yang J, McGann L, Sebald W, Uludag H: RGD-grafted thermoreversible polymers to facilitate attachment of BMP-2 responsive C2C12 cells. Biomaterials26(35), 7329–7338 (2005).Crossref, Medline, CAS, Google Scholar
    • 14  Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ: Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone35(2), 562–569 (2004).Crossref, Medline, CAS, Google Scholar
    • 15  Yang F, Williams CG, Wang D-A et al.: The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells. Biomaterials26(30), 5991–5998 (2005).Crossref, Medline, CAS, Google Scholar
    • 16  Burdick JA, Anseth KS: Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials23(22), 4315–4323 (2002).Crossref, Medline, CAS, Google Scholar
    • 17  Shin H, Temenoff JS, Bowden GC et al.: Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg-Gly-Asp modified hydrogels without dexamethasone and [β]-glycerol phosphate. Biomaterials26(17), 3645–3654 (2005).Crossref, Medline, CAS, Google Scholar
    • 18  Mann BK, West JL: Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. J. Biomed. Mater. Res.60(1), 86–93 (2002).Crossref, Medline, CAS, Google Scholar
    • 19  Mann BK, Gobin AS, Tsai AT, Schmedlen RH, West JL: Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. Biomaterials22(22), 3045–3051 (2001).Crossref, Medline, CAS, Google Scholar
    • 20  Yoon JJ, Song SH, Lee DS, Park TG: Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. Biomaterials25(25), 5613–5620 (2004).Crossref, Medline, CAS, Google Scholar
    • 21  Jun H-W, West JL: Endothelialization of microporous YIGSR/PEG-modified polyurethaneurea. Tissue Eng.11(7–8), 1133–1140 (2005).Crossref, Medline, CAS, Google Scholar
    • 22  Li F, Carlsson D, Lohmann C et al.: Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation. Proc. Natl Acad. Sci. USA100(26), 15346–15351 (2003).Crossref, Medline, CAS, Google Scholar
    • 23  Patel PN, Gobin AS, West JL, Patrick CW: Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. Tissue Eng.11(9–10), 1498–1505 (2005).Crossref, Medline, CAS, Google Scholar
    • 24  Santiago LY, Nowak RW, Rubin JP, Marra KG: Peptide-surface modification of poly(caprolactone) with laminin-derived sequences for adipose-derived stem cell applications. Biomaterials27(15), 2962–2969 (2006).Crossref, Medline, CAS, Google Scholar
    • 25  Gunn JW, Turner SD, Mann BK: Adhesive and mechanical properties of hydrogels influence neurite extension. J. Biomed. Mater. Res.72A(1), 91–97 (2005).Crossref, CAS, Google Scholar
    • 26  Maheshwari G, Brown G, Lauffenburger DA, Wells A, Griffith LG: Cell adhesion and motility depend on nanoscale RGD clustering. J. Cell Sci.113(10), 1677–1686 (2000).Crossref, Medline, CAS, Google Scholar
    • 27  Cukierman E, Pankov R, Stevens DR, Yamada KM: Taking cell-matrix adhesions to the third dimension. Science294(5547), 1708–1712 (2001).Crossref, Medline, CAS, Google Scholar
    • 28  Comisar WA, Hsiong SX, Kong H-J, Mooney DJ, Linderman JJ: Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels. Biomaterials27(10), 2322–2329 (2006).Crossref, Medline, CAS, Google Scholar
    • 29  Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG: Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J. Cell Sci.115(7), 1423–1433 (2002).Crossref, Medline, CAS, Google Scholar
    • 30  Lee KY, Alsberg E, Hsiong S et al.: Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation. Nano Lett.4(8), 1501–1506 (2004).Crossref, Medline, CAS, Google Scholar
    • 31  Fittkau MH, Zilla P, Bezuidenhout D et al.: The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides. Biomaterials26(2), 167–174 (2005).Crossref, Medline, CAS, Google Scholar
    • 32  Shaw D, Shoichet MS: Toward spinal cord injury repair strategies: peptide surface modification of expanded poly(tetrafluoroethylene) fibers for guided neurite outgrowth in vitro. J. Craniofac. Surg.14(3), 308–316 (2003).Crossref, Medline, Google Scholar
    • 33  Mendes SC, Bezemer J, Claase MB et al.: Evaluation of two biodegradable polymeric systems as substrates for bone tissue engineering. Tissue Eng.9(Suppl. 1), S91–S101 (2003).Crossref, Medline, CAS, Google Scholar
    • 34  Laurencin CT, Attawia MA, Lu LQ et al.: Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: a regional gene therapy approach to bone regeneration. Biomaterials22(11), 1271–1277 (2001).Crossref, Medline, CAS, Google Scholar
    • 35  Yao J, Radina S, Leboy PS, Ducheyne P: The effect of bioactive glass content on synthesis and bioactivity of composite poly (lactic-co-glycolic acid)/bioactive glass substrate for tissue engineering. Biomaterials26, 1935–1943 (2005).Crossref, Medline, CAS, Google Scholar
    • 36  Murphy WL, Simmons CA, Kaigler D, Mooney DJ: Bone regeneration via a mineral substrate and induced angiogenesis. J. Dent. Res.83(3), 204–210 (2004).Crossref, Medline, CAS, Google Scholar
    • 37  Leach JK, Kaigler D, Wang Z, Krebsbach PH, Mooney DJ: Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials27(17), 3249–3255 (2006).Crossref, Medline, CAS, Google Scholar
    • 38  Bosetti M, Cannas M: The effect of bioactive glasses on bone marrow stromal cells differentiation. Biomaterials26(18), 3873–3879 (2005).Crossref, Medline, CAS, Google Scholar
    • 39  Xynos ID, Edgar AJ, Buttery LD, Hench LL, Polak JM: Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. J. Biomed. Mater. Res.55(2), 151–157 (2001).Crossref, Medline, CAS, Google Scholar
    • 40  Atala A, Bauer SB, Soker S, Yoo JJ, Retik AB: Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet367(9518), 1241–1246 (2006).Crossref, Medline, Google Scholar
    • 41  Park H, Radisic M, Lim JO, Chang BH, Vunjak-Novakovic G: A novel composite scaffold for cardiac tissue engineering. In Vitro Cell. Dev. Biol. Anim.41(7), 188–196 (2005).Crossref, Medline, CAS, Google Scholar
    • 42  Wang D-A, Williams CG, Yang F et al.: Bioresponsive phosphoester hydrogels for bone tissue engineering. Tissue Eng.11(1–2), 201–213 (2005).Crossref, Medline, CAS, Google Scholar
    • 43  Ehrbar M, Djonov VG, Schnell C et al.: Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth. Circ. Res.94(8), 1124–1132 (2004).Crossref, Medline, CAS, Google Scholar
    • 44  Ehrbar M, Metters A, Zammaretti P, Hubbell JA, Zisch AH: Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J. Control Release101(1–3), 93–109 (2005).Crossref, Medline, CAS, Google Scholar
    • 45  Trentin D, Hall H, Wechsler S, Hubbell JA: Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1{a} variant for local induction of angiogenesis. Proc. Natl Acad. Sci. USA103(8), 2506–2511 (2006).Crossref, Medline, CAS, Google Scholar
    • 46  Sakiyama-Elbert SE, Hubbell JA: Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J. Control Release69(1), 149–158 (2000).Crossref, Medline, CAS, Google Scholar
    • 47  Schmoekel HG, Weber FE, Schense JC et al.: Bone repair with a form of BMP-2 engineered for incorporation into fibrin cell ingrowth matrices. Biotechnol. Bioeng.89(3), 253–262 (2005).Crossref, Medline, CAS, Google Scholar
    • 48  Geer DJ, Swartz DD, Andreadis ST: Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. Am. J. Pathol.167(6), 1575–1586 (2005).Crossref, Medline, CAS, Google Scholar
    • 49  Zisch AH, Lutolf MP, Ehrbar M et al.: Cell-demanded release of VEGF from synthetic, biointeractive cell-ingrowth matrices for vascularized tissue growth. FASEB J.2260–2262 (2003).Crossref, Medline, Google Scholar
    • 50  Seliktar D, Zisch AH, Lutolf MP, Wrana JL, Hubbell JA: MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J. Biomed. Mater. Res. A68A(4), 704–716 (2004).Crossref, CAS, Google Scholar
    • 51  Lutolf MP, Weber FE, Schmoekel HG et al.: Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat. Biotechnol.21(5), 513–518 (2003).Crossref, Medline, CAS, Google Scholar
    • 52  Devine MJ, Mierisch CM, Jang E, Anderson PC, Balian G: Transplanted bone marrow cells localize to fracture callus in a mouse model. J. Orthop. Res.20(6), 1232–1239 (2002).Crossref, Medline, Google Scholar
    • 53  Park J, Ries J, Gelse K et al.: Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes. Gene Ther.10(13), 1089–1098 (2003).Crossref, Medline, CAS, Google Scholar
    • 54  Blum JS, Barry MA, Mikos AG, Jansen JA: In vivo evaluation of gene therapy vectors in ex vivo-derived marrow stromal cells for bone regeneration in a rat critical-size calvarial defect model. Hum. Gene Ther.14(18), 1689–1701 (2003).Crossref, Medline, CAS, Google Scholar
    • 55  Zhao Z, Zhao M, Xiao G, Franceschi RT: Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol. Ther.12(2), 247–253 (2005).Crossref, Medline, CAS, Google Scholar
    • 56  Kuroda R, Usas A, Kubo S et al.: Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum.54(2), 433–442 (2006).Crossref, Medline, CAS, Google Scholar
    • 57  Lavasani M, Lu A, Peng H, Cummins J, Huard J: Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle. Hum. Gene Ther.17(2), 180–192 (2006).Crossref, Medline, CAS, Google Scholar
    • 58  Edwards PC, Ruggiero S, Fantasia J et al.: Sonic hedgehog gene-enhanced tissue engineering for bone regeneration. Gene Ther.12(1), 75–86 (2005).Crossref, Medline, CAS, Google Scholar
    • 59  Peterson B, Zhang J, Iglesias R et al.: Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng.11(1–2), 120–129 (2005).Crossref, Medline, CAS, Google Scholar
    • 60  Madry H, Padera R, Seidel J et al.: Gene transfer of a human insulin-like growth Factor I cDNA enhances tissue engineering of cartilage. Hum. Gene Ther.13(13), 1621–1630 (2002).Crossref, Medline, CAS, Google Scholar
    • 61  Rutherford RB, Moalli M, Franceschi RT et al.: Bone morphogenetic protein-transduced human fibroblasts convert to osteoblasts and form bone in vivo. Tissue Eng.8(3), 441–452 (2002).Crossref, Medline, CAS, Google Scholar
    • 62  Zhao M, Zhao Z, Koh JT, Jin T, Franceschi RT: Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J. Cell. Biochem.95(1), 1–16 (2005).Crossref, Google Scholar
    • 63  Byers BA, Guldberg RE, Hutmacher DW, García AJ: Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects. J. Biomed. Mater. Res. A76A(3), 646–655 (2006).Crossref, CAS, Google Scholar