Review

Peptides and metallic nanoparticles for biomedical applications

† Author for correspondence

Departamento de Química Farmacológica y Toxicológica de la Facultad de Ciencias Químicas y Farmacéuticas, Casilla 233, Universidad de Chile, Olivos 1007, Independencia, Santiago, Chile, and Centro para la Investigación Interdisciplinaria Avanzada en Ciencia de los Materiales, Av. Blanco Encalada 2008, Santiago, Chile.

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Ivonne Olmedo

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Email the corresponding author at i_olmedo@yahoo.com

Leticia Hosta

Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1–5, 08028 Barcelona, Spain.

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Ariel R Guerrero

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Email the corresponding author at arielrgh@hotmail.com

Luis Javier Cruz

Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1–5, 08028 Barcelona, Spain.

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Email the corresponding author at jcruz@pcb.ub.es

Fernando Albericio

† Author for correspondence

Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Josep Samitier 1–5, 08028 Barcelona, Spain.

Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1–11, 08028 Barcelona, Spain.

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Email the corresponding author at falbericio@pcb.ub.es

Published Online:8 Jun 2007https://doi.org/10.2217/17435889.2.3.287

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Abstract

In this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide–nanoparticle conjugates and the synthesis of the peptides and metallic nanoparticles. An overview of the techniques used for the characterization of the conjugates is also provided. Mainly for biomedical purposes, metallic nanoparticles conjugated to peptides have been prepared from Au and iron oxide (magnetic nanoparticles). Peptides with the capacity to penetrate the plasma membrane are used to deliver nanoparticles to the cell. In addition, peptides that recognize specific cell receptors are used for targeting nanoparticles. The potential application of peptide–nanoparticle conjugates in cancer and Alzheimer’s disease therapy is discussed. Several peptide–nanoparticle conjugates show biocompatibility and present a low degree of cytotoxicity. Furthermore, several peptide–metallic nanoparticle conjugates are used for in vitro diagnosis.

Keywords:

Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.

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Published online 8 June 2007

Published in print June 2007

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Acknowledgements

Work in our laboratories was partially supported by: Chile – FONDAP 11980002, FONDECYT 1061142, FONDECYT 7060219; Spain – CICYT (CTQ2006–03794/BQU), ISCIII (CIBER, nanomedicine), the Generalitat de Catalunya (2005SGR 00662), the Institute for Research in Biomedicine and the Barcelona Science Park. MK and FA give special thanks to AECI for providing a Chile–Spain collaboration grant.

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