Published Online:26 Dec 2007https://doi.org/10.2217/17410541.5.1.25
Abstract
Since the complete sequencing of the human genome, the era of the ‘omics’ has appeared. Among them, a new discipline called ‘nutrigenomics’ emerged from the interface of nutrition research and genetics. Its aim is to understand how nutrients modulate gene expression. This powerful tool allows determinination of new biomarkers and the molecular pathways by which our diet may have a potential protective effect against degenerative diseases such as cancer. On one hand, cellular metabolism produces continuous oxidative stress and reactive oxygen species with mutagenic and oncogenic effects. On the other hand, diet provides natural antioxidants present in various fruits and vegetables that may prevent diseases. This review first reports the main antioxidants provided by diet and the main results from epidemiological studies of their role in health. Second, we describe how nutrigenomics could provide new insights into nutrition research and innovative developments through neutraceutical products and a personalized medicine.
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