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Regenerative Medicine

Regenerated teeth: the future of tooth replacement. An update

    Thimios A Mitsiadis

    Author for correspondence:

    E-mail Address: thimios.mitsiadis@zzm.uzh.ch

    Orofacial Development & Regeneration Unit, ZZM, Faculty of Medicine, University of Zurich, Plattenstrasse 11, Zurich CH-8032, Switzerland

    &
    Hidemitsu Harada

    Division of Developmental Biology & Regenerative Medicine, Department of Anatomy, Iwate Medical University, Yahaba, Iwate 028-3694, Japan

    Published Online:https://doi.org/10.2217/rme.14.78
    Free first page

    References

    • 1 Mitsiadis TA, Graf D. Cell fate determination during tooth development and regeneration. Birth Defects Res. C Embryo Today 87(3), 199–211 (2009).
    • 2 Mitsiadis TA, Barrandon O, Rochat A, Barrandon Y, De Bari, C. Stem cell niches in mammals. Exp. Cell Res. 313(16), 3377–3385 (2007).
    • 3 Graziano A, D'Aquino R, Laino G, Papaccio G. Dental pulp stem cells: a promising tool for bone regeneration. Stem Cell Rev. 4(1), 21–26 (2008).
    • 4 Wang L, Shen H, Zheng W et al. Characterization of stem cells from alveolar periodontal ligament. Tissue Eng. Part A 17(7–8), 1015–1026 (2011).
    • 5 Mitsiadis TA, Papagerakis P. Regenerated teeth: the future of tooth replacement? Regen. Med. 6(2), 135–139 (2011).
    • 6 Volponi AA, Pang Y, Sharpe PT. Stem cell-based biological tooth repair and regeneration. Trends Cell Biol. 20(12), 715–722 (2010).
    • 7 Catón J, Bostanci N, Remboutsika E, De Bari C, Mitsiadis TA. Future dentistry: cell therapy meets tooth and periodontal repair and regeneration. J. Cell. Mol. Med. 15(5), 1054–1065 (2011).
    • 8 Jiménez-Rojo L, Granchi Z, Graf D, Mitsiadis TA. Stem cell fate determination during development and regeneration of ectodermal organs. Front. Physiol. 3, 107 (2012).
    • 9 Bluteau G, Luder HU, De Bari C, Mitsiadis TA. Stem cells for tooth engineering. Eur. Cell. Mater. 16, 1–9 (2008).
    • 10 Mitsiadis TA, Woloszyk A, Jiménez-Rojo L. Nanodentistry: combining nanostructured materials and stem cells for dental tissue regeneration. Nanomedicine (Lond.) 7(11), 1743–1753 (2012).
    • 11 Huang GT-J, Yamaza T, Shea LD et al. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng. Part A 16(2), 605–615 (2010).
    • 12 D'Aquino R, De Rosa A, Lanza V et al. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur. Cell. Mater. 18, 75–83 (2009).
    • 13 Yang B, Chen G, Li J et al. Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix-based scaffold. Biomaterials 33(8), 2449–2461 (2012).
    • 14 Shinmura Y, Tsuchiya S, Hata K-I, Honda MJ. Quiescent epithelial cell rests of Malassez can differentiate into ameloblast-like cells. J. Cell. Physiol. 217(3), 728–738 (2008).
    • 15 Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5), 861–872 (2007).
    • 16 Arakaki M, Egusa H, Otsu K, Saitoh I, Miura T, Harada H. Frontier dental research on iPS cells. J. Oral Biosci. 55(4), 191–199 (2013).
    • 17 Arakaki M, Ishikawa M, Nakamura T et al. Role of epithelial-stem cell interactions during dental cell differentiation. J. Biol. Chem. 287(13), 10590–10601 (2012).
    • 18 Otsu K, Kishigami R, Oikawa-Sasaki A et al. Differentiation of induced pluripotent stem cells into dental mesenchymal cells. Stem Cells Dev. 21(7), 1156–1164 (2012).
    • 19 Ferreira L, Karp JM, Nobre L, Langer R. New opportunities: the use of nanotechnologies to manipulate and track stem cells. Cell Stem Cell 3(2), 136–146 (2008).
    • 20 Kraehenbuehl TP, Langer R, Ferreira LS. Three-dimensional biomaterials for the study of human pluripotent stem cells. Nat. Methods 8(9), 731–736 (2011).
    • 21 Dickinson LE, Kusuma S, Gerecht S. Reconstructing the differentiation niche of embryonic stem cells using biomaterials. Macromol. Biosci. 11(1), 36–49 (2011).
    • 22 Mooney DJ, Vandenburgh H. Cell delivery mechanisms for tissue repair. Cell Stem Cell 2(3), 205–213 (2008).
    • 23 Sun H, Jin T, Yu Q, Chen F. Biological approaches toward dental pulp regeneration by tissue engineering. J. Tissue Eng. Regen. Med. 5(4), e1–e16 (2011).
    • 24 Ikeda E, Morita R, Nakao K et al. Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc. Natl Acad. Sci. USA 106(32), 13475–13480 (2009).
    • 25 Oshima M, Mizuno M, Imamura A et al. Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy. PLoS ONE 6(7), e21531 (2011).
    • 26 Oshima M, Inoue K, Nakajima K et al. Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy. Sci. Rep. 4, 6044 (2014).
    • 27 Oshima M, Tsuji T. Functional tooth regenerative therapy: tooth tissue regeneration and whole-tooth replacement. Odontology 102(2), 123–136 (2014).
    • 28 Oshima M, Ogawa M, Yasukawa M, Tsuji T. Generation of a bioengineered tooth by using a three-dimensional cell manipulation method (organ germ method). Methods Mol. Biol. 887, 149–165 (2012).
    • 29 Otsu K, Kumakami-Sakano M, Fujiwara N et al. Stem cell sources for tooth regeneration: current status and future prospects. Front. Physiol. 5, 36 (2014).