In the past few years, bone marrow (BM)-derived cells have been used to regenerate damaged cardiovascular tissues post-myocardial infarction. Recent clinical trials have shown controversial results in recovering damaged cardiac tissue. New progress has shown that the underlying mechanisms of cell-based therapy relies more heavily on humoral and paracrine effects rather than on new tissue generation. However, studies have also reported the potential of new endothelial cell generation from BM cells. Thus, efforts have been made to identify cells having higher humoral or therapeutic effects as well as their surface markers. Specifically, BM-derived CD31⁺ cells were isolated by a surface marker and demonstrated high angio-vasculogenic effects. This article will describe recent advances in the therapeutic use of BM-derived cells and the usefulness of CD31⁺ cells.

Keywords:

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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Vol. 6, No. 3

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Published online 6 May 2011

Published in print May 2011

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Acknowledgement

The authors would like to thank Kenneth Kelly for critical reading of the manuscript.

Financial & competing interests disclosure

This work was supported in part by NIH grants, RO1HL084471, R21HL097353, RC1 GM092035 and HHSN268201000043C (Program of Excellence in Nanotechnology Award), PHS Grant UL1 RR025008 from the Clinical and Translational Science Award program, and Stem Cell Research Center of the 21st Century Frontier Research Program grant SC4300, funded by the Ministry of Science and Technology, Republic of Korea. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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