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Research ArticleFree Access

Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke

    Valeria Battistella

    Department of Neurology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Gabriel R de Freitas

    Department of Neurology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Lea Mirian Barbosa da Fonseca

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Department of Radiology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Daniel Mercante

    Department of Hematology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Bianca Gutfilen

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Department of Radiology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Regina CS Goldenberg

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Juliana Vieira Dias

    Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Tais H Kasai-Brunswick

    Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Eduardo Wajnberg

    Department of Radiology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Paulo Henrique Rosado-de-Castro

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Department of Radiology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    ,
    Soniza V Alves-Leon

    Department of Neurology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    , &
    Charles Andre

    Programa de Terapia Celular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Published Online:https://doi.org/10.2217/rme.10.97

    Aims: To assess the safety and feasibility of intra-arterial transplantation of autologous bone marrow mononuclear cells in patients with middle cerebral artery ischemic stroke within 90 days of symptom onset. Patients & methods: Six patients were included in the study, and they received 1–5 × 108 bone marrow mononuclear cell and were evaluated using blood tests, neurological and imaging examination before treatment, and 1, 3, 7, 30, 60, 90, 120 and 180 days after transplantation. Scintigraphies were carried out 2 and 24 h after the procedure to analyze the biodistribution of labeled cells. Electroencephalogram was conducted within 7 days after transplantation. Results: No patients exhibited any complication or adverse events during the procedure. There was no worsening in the neurological scales until the end of the follow-up. Conclusion: Intra-arterial bone marrow mononuclear cell transplantation is feasible and safe in patients with nonacute ischemic strokes of the middle cerebral artery. Further studies are required to evaluate the efficacy of this therapy.

    Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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