Does the regeneration of hippocampal neurons offer hope for the treatment of cognitive deficits?

Bibliography

• 1  Schöller K, Zausinger S, Baethmann A, Schmid-Elsaesser R: Neuroprotection in ischemic stroke – combination drug therapy and mild hypothermia in a rat model of permanent focal cerebral ischemia. Brain Res.1023,272–278 (2004).
  MedlineGoogle Scholar
• 2  Hagell P, Piccini P, Björklund A et al.: Dyskinesias following neural transplantation in Parkinson’s disease. Nat. Neurosci.5,627–628 (2002).
  Medline CASGoogle Scholar
• 3  Jeltsch H, Yee J, Aloy E et al.: Transplantation of neurospheres after granule cell lesions in rats: cognitive improvements despite no long-term immunodetection of grafted cells. Behav. Brain Res.143,177–191 (2003).
  MedlineGoogle Scholar
• 4  Lindvall O: Neural transplantation in Parkinson’s disease. Novartis Found. Symp.231,110–123; discussion: 123–128, 145–147 (2000).
  Medline CASGoogle Scholar
• 5  Will B, Kelche C, Cassel JC: Intracerebral transplants and memory dysfunction: circuitry repair or functional level setting?. Neural Plast.7,93–108 (2000).
  Medline CASGoogle Scholar
• 6  Lindvall O, Hagell P: Role of cell therapy in Parkinson disease. Neurosurg. Focus13,e2 (2002).
  MedlineGoogle Scholar
• 7  Alvarez-Bullya A, Garcia-Verdugo JM: Neurogenesis in adult subventricular zone. J. Neurosci.22,629–634 (2002).
  MedlineGoogle Scholar
• 8  Kempermann G, Jessberger S, Steiner B, Kronenberg G: Milestones of neuronal development in the adult hippocampus. Trends Neurosci.27,447–452 (2004).
  Medline CASGoogle Scholar
• 9  Sutherland RJ, Whishaw IQ, Kolb B: A behavioural analysis of spatial localization following electrolytic, kainite- or colchicine-induced damage to the hippocampal formation in the rat. Behav. Brain Res.7,133–153 (1983).
  Medline CASGoogle Scholar
• 10  Xavier GF, Oliveira-Filho JB, Santos AMG: Dentate gyrus-selective colchicine lesion and disruption of performance in spatial tasks: difficulties in “place strategy” because of a lack of flexibility in the use of environmental cues. Hippocampus9,668–681 (1999).
  Medline CASGoogle Scholar
• 11  Leutgeb JK, Leutgeb S, Moser M-B, Moser EI: Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science315,961–966 (2007).
  Medline CASGoogle Scholar
• 12  Sloviter RS, Valiquette G, Abrams GM et al.: Selective loss of hippocampal granule cells in the mature rats brain after adrenalectomy. Science243,535–538 (1989).
  Medline CASGoogle Scholar
• 13  Woolley CS, Gould E, Sakai RR, Spencer RL, McEwen BS: Effects of aldosterone or RU 28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat. Brain Res.554,312–315 (1991).
  Medline CASGoogle Scholar
• 14  Spanswick SC, Sutherland RJ: Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats. Learn. Mem.17,241–245 (2010).
  Medline CASGoogle Scholar
• 15  Spanswick SC, Epp JR, Keith JR, Sutherland RJ: Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine. Hippocampus17,137–146 (2007).
  Medline CASGoogle Scholar
• 16  Fernando CV, Moses D, Parish CL, Tomas D, Drago J, Horne MK: Creating a ventral midbrain stem cell niche in an animal model for Parkinson’s disease. Stem Cells Dev.19(12),1995–2007 (2010).
  Medline CASGoogle Scholar
• 17  Shimado IS, Peterson BM, Spees JL: Isolation of locally derived stem/progenitor cells from the peri-infarct area that do not migrate from the lateral ventricle after cortical stroke. Stroke41,e552–e560 (2010).
  MedlineGoogle Scholar
• 18  Young C, Brooks K, Buchan AM, Szele F: Cellular and molecular determinants of stroke induced changes in subventricular zone cell migration. Antioxid. Redox Signal. doi: 10.1089/ars.2010.3435 (2010) (Epub ahead of print).
  Google Scholar
• 19  Mu Y, Lee SW, Gage FH: Signaling in adult neurogenesis. Curr. Opin. Neurobiol.4,416–423 (2010).
  Google Scholar
• 20  Gonzalez-Perez O, Quiñones-Hinjosa A, Garcia-Verdugo JM: Immunological control of adult neural stem cells. J. Stem Cells5,23–31 (2010).
  MedlineGoogle Scholar
• 21  Molina-Holgado E, Molina-Holgado F: Mending the broken brain: neuroimmune interactions in neurogenesis. J. Neurochem.114,1277–1290 (2010).
  Medline CASGoogle Scholar