Abstract
In this article, we compare two different approaches to establishing stem cell policy: a defined policy (the UK) and a changing policy (the US). The UK has a clear and precise policy, agreed upon and supported by lawmakers, scientists and the public. By contrast, US federal policy is continuously being updated based on balancing political ideologies and advances in science, and it only regulates federal funding. By investigating these contrasting policy approaches, we hope to demonstrate the impact of policy on stem cell research and public opinion.
Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest
Bibliography
- 1 Salter B, Harvey O: Stem cell innovation in the USA: the benefits of the minimal state. Regen. Med.3(4),597–610 (2008).
- 2 Warnock M: Report of the committee of inquiry into human fertilisation and embryology. Stationary Office BooksUK (1984).▪ The Warnock report is a famous review and set of recommendations related to the ethical and moral impact of human embryo research. The report resulted in the creation of the Human Fertilisation and Embryology Authority (HFEA) in the UK and the limit of 14 days of development on human embryo research.
- 3 Cressey D: UK embryo agency faces the axe. Nature466,674 (2010).
- 4 Cressey D: Quango bonfire kindles advice fears. Nature467,895–896 (2010).
- 5 National Bioethics Advisory Commission: Cloning Human Beings: Report and recommendations of the National Bioethics Advisory Commission. Rockville, MD, USA (1997).
- 6 National Bioethics Advisory Commission: Ethical Issues in Human Embryonic Stem Cell Research, Volume I, Report and recommendations of the National Bioethics Advisory Commission. Rockville, MD, USA (1998).
- 7 Harris G: Stem cell financing ban ends, for now. NY Times, 9 September (2010).
- 8 Levine AD: Research policy and the mobility of US stem cell scientists. Nat. Biotechnol.24(7),865–866 (2006).
- 9 Winston RML: Does government regulation inhibit embryonic stem cell research and can it be effective? Cell Stem Cell1(1),27–34 (2007).
- 10 Noll R: Designing an effective programme of state-sponsored human embryonic stem cell research. Berkeley Technol. Law J.21(3),1143–1174 (2006).
- 11 National Academies: Guidelines for Human Embryonic Stem Cell Research. National Academy Press, Washington DC, USA (2005).
- 12 Nolan JM, Samad EU, Martins SAR, Brozak SG: The Bankers: US firms could be left behind. Nature467,1032–1033 (2010).
- 13 Owen-Smith J, McCormick J: An international gap in human ES cell research. Nat. Biotechnol.24(4),391–392 (2006).
- 14 Levine AD: Identifying under- and overperforming countries in research related to human embryonic stem cells. Cell Stem Cell2,521–524 (2008).
- 15 Levine AD: Trends in the geographic distribution of human embryonic stem-cell research. Politics Life Sci.23(2),40–45 (2005).
- 16 Pollack A: FDA approves a stem cell trial. NY Times, 23 January (2009).
- 17 Caulfield T, Zarzeczny A, McCormick J et al.: The stem cell research environment: a patchwork of patchworks. Stem Rev. Rep.5(2),82–88 (2009).
- 18 Downey R, Geransar R: Stem cell research, publics, and stakeholder views. Health Law Rev.16(2),70–85 (2008).
- 19 Gottweis H, Prainsack B: Emotion in political discourse: contrasting approaches to stem cell governance in the USA, UK, Israel, and Germany. Regen. Med.1(6),823–829 (2006).
- 101 Stem Cell Policy: World Stem Cell Map www.aei.org/outlook/100997
- 102 UK Stem Cell Initiative: Report and recommendations, Department of Health (2006) www.dh.gov.uk/ab/UKSCI
- 103 UK Medical Research Council www.mrc.ac.uk
- 104 NIH www.nih.gov
- 105 National Statistics Online www.statistics.gov.uk/cci/nugget.asp?id=6
- 106 American FactFinder http://factfinder.census.gov
- 107 Matthews KR, Rowland M: Stem Cell Policy in the Obama Age: Texas, US, and UK Perspectives, a September 2009 Conference Report. Baker Institute for Public Policy, Houston, TX, USA (2010) www.bakerinstitute.org/publications/ST-PUB-StemCellConfReport.pdf▪▪ Describes in detail the histories and politics involved in creating stem cell policies in the UK and the US.
- 108 Baker Institute events, “Stem Cells: Saving Lives or Crossing Lines, Part V: Texas–UK Collaboration” www.bakerinstitute.org/events/txukstemcell09
- 109 Baker Institute events, “Stem Cell Policy in the Obama Age” www.bakerinstitute.org/events/stemcelldinner09
- 110 The Human Fertilisation and Embryology Act of 1990 www.hfea.gov.uk/2070.html
- 111 The Human Fertilisation and Embryology (Research Purposes) Regulations: S.I. 2001/188, part 2, paragraph 2 (UK) www.opsi.gov.uk/SI/si2001/20010188.htm
- 112 Human Fertilization and Embryology Authority. Hybrids and Chimeras: A consultation on the ethical and social implications of creating human–animal embryos in researchwww.hfea.gov.uk/docs/Hybrids_Chimera_review.pdf
- 113 Human Fertilisation and Embryology Authority, Annual Report and Accounts 2009/10 www.hfea.gov.uk/docs/Annual_Report_2010_Web_reduced.pdf
- 114 UK Department of Health, “Liberating the NHS: Report of the arm’s-length bodies review” www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/@ps/documents/digitalasset/dh_118053.pdf
- 115 US Dept. Health and Human Services: Title 45 ‘Public Welfare,’ Part 46, ‘Protection of Human Subjects.’ In: Code of Federal Regulationswww.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm
- 116 The Library of Congress (THOMAS) http://thomas.loc.gov/
- 117 Human Embryonic Stem Cell Policy Under Former President Bush http://stemcells.nih.gov/policy/2001policy.htm
- 118 Obama B: Removing Barriers for Responsible Scientific Research Involving Human Stem Cells. In: Executive Order. 9 March (2009) www.whitehouse.gov/the_press_office/Removing-Barriers-to-Responsible-Scientific-Research-Involving-Human-Stem-cells/
- 119 U.S. District Court for the District of Columbia ruling Aug 31, 2010, Sherley vs. Sebeliushttps://ecf.dcd.uscourts.gov/cgi-bin/show_public_doc?2009cv1575–44
- 120 Matthews KR: Stem Cell Research: A Science and Policy Overview. Baker Institute for Public Policy, Houston, TX, USA (2009) www.bakerinstitute.org/publications/stemcell-intro-0208.pdf▪▪ This overview, which is updated annually, reviews the history of stem cell policy in the US. Created for a general audience, it also lists US state policies, as well as national policies from countries around the world.
- 121 National Conference of State Legislators: Stem Cell Research www.ncsl.org/IssuesResearch/Health/EmbryonicandFetalResearchLaws/tabid/14413/Default.aspx
- 122 South Dakota Statute Chapter 34–14 “Medical Research” http://legis.state.sd.us/statutes/DisplayStatute.aspx?Statute=34–14&Type=Statute
- 123 California Institute of Regenerative Medicine www.cirm.ca.gov
- 124 Louisiana Sec 14: 87.2 Human experimentation www.legis.state.la.us/lss/lss.asp?doc=78690
- 125 Missouri Constitution, Article III, Section 38d, “Missouri Stem Cell Research and Cures Initiative” 28 August (2009) www.moga.mo.gov/const/a03038d.htm
- 126 National Science Board: Financial Research and Development Input. In: Science and Engineering Indicators 2010. National Science Foundation, Arlington, VA, USA (2010) www.nsf.gov/statistics/seind10/
- 127 US Department of Health and Human Services: 2020: a new vision. A future for regenerative medicine. US DHHS, Washington DC, USA (2006) www.hhs.gov/reference/newfuture.shtml
- 128 International Society for Stem Cell Research (ISSCR): Guidelines for the Conduct of Human Embryonic Stem Cells (2006) www.isscr.org/guidelines/ISSCRhESCguidelines2006.pdf
- 129 VCU Life Sciences Survey 2010 www.vcu.edu/lifesci/images2/survey2010.pdf