We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Do stem cell-derived islets represent a commercially viable treatment for Type 1 and 2 diabetes?

    Adrianne L Wong

    Juvenile Diabetes Research Foundation International, 26 Broadway, 14th floor, NY 10004, USA

    &
    Concepcion R Nierras

    † Author for correspondence

    Juvenile Diabetes Research Foundation International, 26 Broadway, 14th floor, NY 10004, USA.

    Published Online:https://doi.org/10.2217/rme.10.75
    Free first page

    Bibliography

    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group: Modern-day clinical course of Type 1 diabetes mellitus after 30 years’ duration. Arch. Intern. Med.169,1307–1316 (2009).
    • Robertson RP: Islet transplantation a decade later and strategies for filling a half full glass. Diabetes59,1285–1291 (2010).
    • Fiorina P, Shapiro AMJ, Ricordi C, Secci A: The clinical impact of islet transplantation. Am. J. Transplant.8,1990–1997 (2008).
    • Thompson DM, Begg IS, Harris C et al.: Reduced progression of diabetic retinopathy after islet cell transplantation compared with intensive medical therapy. Transplantation85,1400–1405 (2008).
    • Tharavanij T, Betancourt A, Messinger S et al.: Improved long-term health-related quality of life after islet transplantation. Transplantation86,1161–1167 (2008).
    • Nierras CR, Stallard J, Goldstein RA, Insel R: Human embryonic stem cell research and the Juvenile Diabetes Research Foundation International – a work in progress. Pediatr. Diabetes5(Suppl. 2),94–97 (2004).
    • Aguayo-Mazzucato C, Bonner-Weir S: Stem cell therapy for Type 1 diabetes mellitus. Nat. Rev. Endocrinol.6,139–148 (2010).
    • McKernan R, McNeish J, Smith D: Pharma’s developing interest in stem cells. Cell Stem Cell6,517–520 (2010).
    • Borowiak M, Melton DA: How to make β cells? Curr. Opin. Cell Biol.21,727–732 (2009).
    • 10  Puri S, Hebrok M: Cellular plasticity within the pancreas – lessons learned from development. Dev. Cell18,342–356 (2010).
    • 11  Jiang J, Au M, Lu K et al.: Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells25,1940–1953 (2007).
    • 12  D’Amour KA, Bang AG, Eliazar S et al.: Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol.24,1392–1401 (2006).
    • 13  Kroon E, Martinson LA, Kadoya K et al.: Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol.26,443–452 (2008).
    • 14  Placzek MR, Chung IM, Macedo HM et al.: Stem cell bioprocessing: fundamentals and principles. J. R. Soc. Interface6,209–232 (2009).
    • 15  McCall MD, Toso C, Baetge EE, Shapiro AM: Are stem cells a cure for diabetes? Clin. Sci.118,87–97 (2009).
    • 16  Vendrame F, Pileggi A, Laughlin E et al.: Recurrence of Type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic CD4 T-cells. Diabetes59,947–957 (2010).
    • 17  Korsgren O, Nilsson B: Improving islet transplantation: a roadmap for widespread application for the cure of persons with Type 1 diabetes. Curr. Opin. Organ Transplant.14,683–687 (2009).
    • 18  Beckwith J, Nyman JA, Flanagan B et al.: A health-economic analysis of porcine islet xenotransplantation. Xenotransplantation17,233–242 (2010).
    • 19  O’Connell P: The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in Type 1 diabetes – chapter 6: patient selection for pilot clinical trials of islet xenotransplantation. Xenotransplantation16,249–254 (2009).
    • 101  Centers for Disease Control and Prevention: National Diabetes Fact Sheet www.cdc.gov/diabetes/pubs/general07.htm#what
    • 102  American Diabetes Association: the cost of diabetes www.diabetes.org/advocate/resources/cost-of-diabetes.html
    • 103  Next generation β-cell transplantation www.niddk.nih.gov/fund/other/nextgenbeta/
    • 104  Baker M, Carpenter M: Making stem cells for many, safely. Nature Reports Stem Cells www.nature.com/stemcells/2009/0908/090827/full/stemcells.2009.113.html