We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine
Published Online:https://doi.org/10.2217/pgs.13.113
Free first page

References

  • Ellis MJ, Ding L, Shen D et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature486(7403),353–360 (2012).
  • Banerji S, Cibulskis K, Rangel-Escareno C et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature486(7403),405–409 (2012).
  • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature487(7407),330–337 (2012).
  • ENCODE Project Consortium, Dunham I, Kundaje A et al. An integrated encyclopedia of DNA elements in the human genome. Nature489(7414),57–74 (2012).
  • Stamatoyannopoulos JA. What does our genome encode? Genome Res.22(9),1602–1611 (2012).
  • Maurano MT, Humbert R, Rynes E et al. Systematic localization of common disease-associated variation in regulatory DNA. Science337(6099),1190–1195 (2012).
  • Gerstein MB, Kundaje A, Hariharan M et al. Architecture of the human regulatory network derived from ENCODE data. Nature489(7414),91–100 (2012).
  • He Y, Fang J, Taatjes DJ, Nogales E. Structural visualization of key steps in human transcription initiation. Nature495(7442),481–486 (2013).
  • Chung K, Wallace J, Kim SY et al. Structural and molecular interrogation of intact biological systems. Nature497(7449),332–337 (2013).
  • 10  Pelechano V, Wei W, Steinmetz LM. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature497(7447),127–131 (2013).
  • 11  Pugh BF. Molecular biology: the ends justify the means. Nature497(7447),48–49 (2013).
  • 12  Roukos DH, Ziogas DE, Baltogiannis GG et al. Novel next-generation sequencing and networks-based therapeutic targets: realistic more effective drug design and discovery. Curr. Pharm. Des. doi:10.2174/13816128113199990385 (2013) (Epub ahead of print).
  • 13  Erler JT, Linding R. Network medicine strikes a blow against breast cancer. Cell149(4),731–733 (2012).
  • 14  Martin-Castillo B, Oliveras-Ferraros C, Vazquez-Martin A et al. Basal/HER2 breast carcinomas integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Cell Cycle12(2),225–245 (2013).
  • 15  Shaw AT, Kim DW, Nakagawa K et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med.368,2385–2394 (2013)
  • 16  Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell144(5),646–674 (2011).
  • 17  Ideker T, Krogan NJ. Differential network biology. Mol. Syst. Biol.8,565 (2012).
  • 18  Zhang QC, Petrey D, Garzón JI, Deng L, Honig B. PrePPI: a structure-informed database of protein-protein interactions. Nucleic Acids Res.41(D1),D828–D833 (2013).
  • 19  Cheng TM, Gulati S, Agius R, Bates PA. Understanding cancer mechanisms through network dynamics. Brief Funct.Genomics11(6),543–560 (2012).
  • 20  Depry C, Mehta S, Zhang J. Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors. Pflugers Arch.465(3),373–381 (2013).
  • 101  US FDA. Cetuximab in Combination with Folfiri/Therascreen. www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm310933.htm