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Short Communication

Genetic variants associated with warfarin dosage in Kuwaiti population

    Sumi Elsa John

    Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

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    ,
    Dinu Antony

    Functional Genomics Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

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    ,
    Muthukrishnan Eaaswarkhanth

    Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

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    ,
    Prashantha Hebbar

    Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

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    ,
    Fadi Alkayal

    Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

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    ,
    Jaakko Tuomilehto

    Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

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    ,
    Osama Alsmadi‡

    Functional Genomics Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

    ‡Authors contributed equally

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    &
    Thangavel Alphonse Thanaraj‡

    *Author for correspondence:

    E-mail Address: alphonse.thangavel@dasmaninstitute.org

    Population Genomics & Genetic Epidemiology Unit, Dasman Diabetes Institute, P.O. Box 1180, Dasman, 15462, Kuwait

    ‡Authors contributed equally

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    Published Online:8 Jun 2017https://doi.org/10.2217/pgs-2017-0020

    Abstract

    Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590_A/CYP2A7, rs2108622_T/CYP4F2, rs2884737_C/VKORC1 and distinct absence of rs11150606_C/PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.

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