Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population

References

• 1 Weir MR, Henrich WL. Theoretical basis and clinical evidence for differential effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor subtype 1 blockers. Curr. Opin. Nephrol. Hypertens. 9(4), 403–411 (2000).
  Medline CASGoogle Scholar
• 2 The National Board of Health and Welfare, the Swedish Prescribed Drug Register (2015). www.socialstyrelsen.se/tatistik/statistikdatabas/lakemedel.
  Google Scholar
• 3 Dicpinigaitis PV. Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Chest 129(Suppl. 1), S169–S173 (2006).
  Medline CASGoogle Scholar
• 4 Wyskida K, Jura-Szoltys E, Smertka M, Owczarek A, Chudek J. Factors that favor the occurrence of cough in patients treated with ramipril: a pharmacoepidemiological study. Med. Sci. Monit. 18(9), PI21–PI28 (2012).
  MedlineGoogle Scholar
• 5 Morimoto T, Gandhi TK, Fiskio JM et al. An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors. J. Eval. Clin. Pract. 10(4), 499–509 (2004).
  MedlineGoogle Scholar
• 6 Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology. Ann. Intern. Med. 117(3), 234–242 (1992).
  Medline CASGoogle Scholar
• 7 Powers BJ, Coeytaux RR, Dolor RJ et al. Updated report on comparative effectiveness of ACE inhibitors, ARBs, and direct renin inhibitors for patients with essential hypertension: much more data, little new information. J. Gen. Intern. Med. 27(6), 716–729 (2012).
  MedlineGoogle Scholar
• 8 Fox AJ, Lalloo UG, Belvisi MG, Bernareggi M, Chung KF, Barnes PJ. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat. Med. 2(7), 814–817 (1996).
  Medline CASGoogle Scholar
• 9 Mukae S, Itoh S, Aoki S et al. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. J. Hum. Hypertens. 16(12), 857–863 (2002).
  Medline CASGoogle Scholar
• 10 Mukae S, Aoki S, Itoh S, Iwata T, Ueda H, Katagiri T. Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. Hypertension 36(1), 127–131 (2000).
  Medline CASGoogle Scholar
• 11 Mas S, Gasso P, Alvarez S et al. Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes. Pharmacogenet. Genomics 21(9), 531–538 (2011).
  Medline CASGoogle Scholar
• 12 Grilo A, Saez-Rosas MP, Santos-Morano J et al. Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough. Pharmacogenet. Genomics 21(1), 10–17 (2011).
  Medline CASGoogle Scholar
• 13 Kim TB, Oh SY, Park HK et al. Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough. J. Clin. Pharm. Ther. 34(4), 457–464 (2009).
  Medline CASGoogle Scholar
• 14 Mosley JD, Shaffer CM, Van Driest SL et al. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. Pharmacogenomics J. 16(3), 231–237 (2016).
  Medline CASGoogle Scholar
• 15 SWEDEGENE. www.swedegene.se.
  Google Scholar
• 16 Hallberg P, Nagy J, Karawajczyk M et al. Comparison of clinical factors between patients with angiotensin-converting enzyme inhibitor-induced angioedema and cough. Ann. Pharmacother. doi:10.1177/1060028016682251 (2016) (Epub ahead of print).
  Google Scholar
• 17 Magnusson PK, Almqvist C, Rahman I et al. The Swedish Twin Registry: establishment of a biobank and other recent developments. Twin Res. Hum. Genet. 16(1), 317–329 (2013).
  MedlineGoogle Scholar
• 18 Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19(1), 149–150 (2003).
  Medline CASGoogle Scholar
• 19 Das S, Forer L, Schönherr S et al. Next-generation genotype imputation service and methods. Nat. Genet. 48, 1284–1287 (2016).
  Medline CASGoogle Scholar
• 20 Loh P, Danecek P, Palamara PF et al. Reference-based phasing using the Haplotype Reference Consortium panel (2016). Nat. Genet. 48(11), 1443–1448 (2016).
  Medline CASGoogle Scholar
• 21 McCarthy S, Das S, Kretzschmar W et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat. Genet. 48, 1279–1283 (2016).
  Medline CASGoogle Scholar
• 22 Sham PC, Purcell SM. Statistical power and significance testing in large-scale genetic studies. Nat. Rev. Genet. 15(5), 335–346 (2014).
  Medline CASGoogle Scholar
• 23 Takeyama K, Dabbagh K, Lee HM et al. Epidermal growth factor system regulates mucin production in airways. Proc. Natl Acad. Sci. USA 96(6), 3081–3086 (1999).
  Medline CASGoogle Scholar
• 24 Uniprot C. UniProt: a hub for protein information. Nucleic Acids Res. 43, D204–D212 (2015).
  MedlineGoogle Scholar
• 25 Roadmap Epigenomics Consortium, Kundaje A, Meuleman W et al. Integrative analysis of 111 reference human epigenomes. Nature 518(7539), 317–330 (2015).
  MedlineGoogle Scholar
• 26 ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414), 57–74 (2012).
  MedlineGoogle Scholar
• 27 Nishio K, Kashiki S, Tachibana H, Kobayashi Y. Angiotensin-converting enzyme and bradykinin gene polymorphisms and cough: a meta-analysis. World J. Cardiol. 3(10), 329–336 (2011).
  MedlineGoogle Scholar
• 28 Zee RY, Rao VS, Paster RZ, Sweet CS, Lindpaintner K. Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis. Hypertension 31(4), 925–928 (1998).
  Medline CASGoogle Scholar
• 29 Woo SW, Bang S, Chung MW, Jin SK, Kim YS, Lee SH. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. J. Clin. Pharm. Ther. 34(5), 561–567 (2009).
  Medline CASGoogle Scholar
• 30 Uhlen M, Fagerberg L, Hallstrom BM et al. Proteomics. Tissue-based map of the human proteome. Science 347(6220), 1260419 (2015).
  MedlineGoogle Scholar
• 31 Akhmanova A, Hoogenraad CC, Drabek K et al. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell 104(6), 923–935 (2001).
  Medline CASGoogle Scholar
• 32 Rida PC, Livecche D, Ogden A, Zhou J, Aneja R. The Noscapine Chronicle: a pharmaco-historic biography of the opiate alkaloid family and its clinical applications. Med. Res. Rev. 35(5), 1072–1096 (2015).
  Medline CASGoogle Scholar
• 33 Mahmoudian M, Mojaverian N. Efffect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced smooth muscle contraction in the isolated ileum of the guinea-pig. Acta Physiol. Hung. 88(3–4), 231–237 (2001).
  Medline CASGoogle Scholar
• 34 Ye K, Ke Y, Keshava N et al. Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. Proc. Natl Acad. Sci. USA 95(4), 1601–1606 (1998).
  Medline CASGoogle Scholar
• 35 Mooraki A, Jenabi A, Jabbari M et al. Noscapine suppresses angiotensin converting enzyme inhibitors-induced cough. Nephrology (Carlton) 10(4), 348–350 (2005).
  Medline CASGoogle Scholar
• 36 Singh B, Coffey RJ. From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease. Semin. Cell Dev. Biol. 28, 12–21 (2014).
  Medline CASGoogle Scholar
• 37 Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 14(17), 2123–2133 (2000).
  Medline CASGoogle Scholar
• 38 Xie S, Issa R, Sukkar MB et al. Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Respir. Res. 6, 148 (2005).
  MedlineGoogle Scholar
• 39 Rogers NK, Clements D, Dongre A, Harrison TW, Shaw D, Johnson SR. Extra-cellular matrix proteins induce matrix metalloproteinase-1 (MMP-1) activity and increase airway smooth muscle contraction in asthma. PLoS ONE 9(2), e90565 (2014).
  MedlineGoogle Scholar
• 40 Bruce C, Thomas PS. The effect of marimastat, a metalloprotease inhibitor, on allergen-induced asthmatic hyper-reactivity. Toxicol. Appl. Pharmacol. 205(2), 126–132 (2005).
  Medline CASGoogle Scholar
• 41 Bender AT, Beavo JA. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol. Rev. 58(3), 488–520 (2006).
  Medline CASGoogle Scholar
• 42 Rabe KF, Bateman ED, O'Donnell D, Witte S, Bredenbroker D, Bethke TD. Roflumilast-an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 366(9485), 563–571 (2005).
  Medline CASGoogle Scholar
• 43 Garnock-Jones KP. Roflumilast: a review in COPD. Drugs 75(14), 1645–1656 (2015).
  Medline CASGoogle Scholar
• 44 Ebrahimi SA, Saghaeian-Shahri T, Shafiei M, Rostami P, Mahmoudian M. Interaction of papaverine with the enalapril-induced cough in guinea pig. Acta Physiol. Hung. 93(1), 71–78 (2006).
  Medline CASGoogle Scholar
• 45 Dewan AT, Triche EW, Xu X et al. PDE11A associations with asthma: results of a genome-wide association scan. J. Allergy Clin. Immunol. 126(4), 871e879–873e879 (2010).
  Google Scholar
• 46 Maranville JC, Cox NJ. Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits. Pharmacogenomics J. 16(4), 388–392 (2016).
  Medline CASGoogle Scholar
• 47 Relling MV, Evans WE. Pharmacogenomics in the clinic. Nature 526(7573), 343–350 (2015).
  Medline CASGoogle Scholar