Review

School of Molecular Bioscience, University of Sydney, NSW 2006, Australia; School of Molecular Bioscience G08, University of Sydney, NSW 2006, Australia

The Heart Research Institute, Sydney, NSW 2042, Australia

Anna Waterhouse

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA

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Alexey Kondyurin

School of Physics, University of Sydney, NSW 2006, Australia

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Marcela M Bilek

School of Physics, University of Sydney, NSW 2006, Australia

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Anthony S Weiss

* Author for correspondence

Bosch Institute, University of Sydney, Sydney, 2006, Australia.

Charles Perkins Centre, University of Sydney, Sydney, 2006, Australia

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Email the corresponding author at tony.weiss@sydney.edu.au

Published Online:18 Dec 2012https://doi.org/10.2217/nnm.12.161

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Abstract

Polymeric and metallic materials are used extensively in permanently implanted cardiovascular devices and devices that make temporary but often prolonged contact with body fluids and tissues. Foreign body responses are typically triggered by host interactions at the implant surface, making surface modifications to increase biointegration desirable. Plasma-based treatments are extensively used to modify diverse substrates; modulating surface chemistry, wettability and surface roughness, as well as facilitating covalent biomolecule binding. Each aspect impacts on facets of vascular compatibility including endothelialization and blood contact. These modifications can be readily applied to polymers such as Dacron^® and expanded polytetrafluoroethylene, which are widely used in bypass grafting and the metallic substrates of stents, valves and pacemaker components. Plasma modification of metals is more challenging given the need for coating deposition in addition to surface activation, adding the necessity for robust interface adhesion. This review examines the evolving plasma treatment technology facilitating the biofunctionalization of polymeric and metallic implantable cardiovascular materials.

Keywords:

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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Published online 18 December 2012

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Financial & competing interests disclosure

The authors acknowledge funding support from the Australian Research Council, the National Health and Medical Research Council and The Baird Institute. AS Weiss is the Scientific Founder of Elastagen Pty Ltd. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Plasma-based biofunctionalization of vascular implants

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