Nanomaterial-assisted laser desorption ionization for mass spectrometry-based biomedical analysis

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Bibliography

• 1  Karas M, Bachmann D, Bahr U, Hillenkamp F: Matrix-assisted ultraviolet-laser desorption of nonvolatile compounds. Int. J. Mass Spectrom. Ion Process.78,53–68 (1987).
  CASGoogle Scholar
• 2  Yamashita M, Fenn JB: Electrospray ion-source – another variation on the free-jet theme. J. Phys. Chem.88(20),4451–4459 (1984).
  CASGoogle Scholar
• 3  Karas M, Gluckmann M, Schafer J: Ionization in matrix-assisted laser desorption/ionization: singly charged molecular ions are the lucky survivors. J. Mass Spectrom.35(1),1–12 (2000).
  Medline CASGoogle Scholar
• 4  Tanaka K, Waki H, Ido Y et al.: Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom.2(8),151–153 (1988).▪▪ The first laser desorption/ionization (LDI) publication.
  CASGoogle Scholar
• 5  Wei J, Buriak JM, Siuzdak G: Desorption-ionization mass spectrometry on porous silicon. Nature399(6733),243–246 (1999).▪ The most widely used LDI method.
  Medline CASGoogle Scholar
• 6  Huikko K, Ostman P, Sauber C et al.: Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs. Rapid Commun. Mass Spectrom.17(12),1339–1343 (2003).
  Medline CASGoogle Scholar
• 7  Laiko VV, Taranenko NI, Berkout VD, Musselman BD, Doroshenko VM: Atmospheric pressure laser desorption/ionization on porous silicon. Rapid Commun. Mass Spectrom.16(18),1737–1742 (2002).
  Medline CASGoogle Scholar
• 8  Ostman P, Pakarinen JMH, Vainiotalo P, Franssila S, Kostiainen R, Kotiaho T: Minimum proton affinity for efficient ionization with atmospheric pressure desorption/ionization on silicon mass spectrometry. Rapid Commun. Mass Spectrom.20(24),3669–3673 (2006).
  Medline CASGoogle Scholar
• 9  Pihlainen K, Grigoras K, Franssila S, Ketola R, Kotiaho T, Kostiainen R: Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures. J. Mass Spectrom.40(4),539–545 (2005).
  Medline CASGoogle Scholar
• 10  Yoon SH, Gamage CM, Gillig KJ, Wysocki VH: Kinetics of surface-induced dissociation of N(CH₃)₄⁺ and N(CD₃)₄⁺ using silicon nanoparticle assisted laser desorption/ionization and laser desorption/ionization. J. Am. Soc. Mass Spectrom.20(6),957–964 (2009).
  Medline CASGoogle Scholar
• 11  Bhattacharya SH, Raiford TJ, Murray KK: Infrared laser desorption/ionization on silicon. Anal. Chem.74(9),2228–2231 (2002).
  Medline CASGoogle Scholar
• 12  Go EP, Apon JV, Luo G et al.: Desorption/ionization on silicon nanowires. Anal. Chem.77(6),1641–1646 (2005).
  Medline CASGoogle Scholar
• 13  Lee CS, Kang KK, Kim JH et al.: Analysis of small molecules by desorption/ionization on mesoporous silicate (DIOM)-mass spectrometry (MS). Microporous Mesoporous Mater.98(1–3),200–207 (2007).
  CASGoogle Scholar
• 14  Lee CS, Song HM, Kang KK, Choi CH, Rhee HK, Kim BG: Desorption/ionization on mesoporous silicate (DIOM)-mass spectrometry (MS) and ultrafiltration for target-based drug screening. Biochip J.1(1),43–48 (2007).
  Google Scholar
• 15  Gorecka-Drzazga A, Bargiel S, Walczak R et al.: Desorption/ionization mass spectrometry on porous silicon dioxide. Sens. Actuators B Chem.103(1–2),206–212 (2004).
  CASGoogle Scholar
• 16  Novikov A, Caroff M, Della-Negra S et al.: Matrix-implanted laser desorption/ionization mass spectrometry. Anal. Chem.76(24),7288–7293 (2004).
  Medline CASGoogle Scholar
• 17  Wu HP, Yu CJ, Lin CY, Lin YH, Tseng WL: Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry. J. Am. Soc. Mass Spectrom.20(5),875–882 (2009).
  Medline CASGoogle Scholar
• 18  Kawasaki H, Sugitani T, Watanabe T, Yonezawa T, Moriwaki H, Arakawa R: Layer-by-layer self-assembled mutilayer films of gold nanoparticles for surface-assisted laser desorption/ionization mass spectrometry. Anal. Chem.80(19),7524–7533 (2008).
  Medline CASGoogle Scholar
• 19  Love JC, Estroff LA, Kriebel JK, Nuzzo RG, Whitesides GM: Self-assembled monolayers of thiolates on metals as a form of nanotechnology. Chem. Rev.105,1103–1169 (2005).
  Medline CASGoogle Scholar
• 20  Castellana ET, Russell DH: Tailoring nanoparticle surface chemistry to enhance laser desorption ionization of peptides and proteins. Nano Lett.7,3023–3025 (2007).
  Medline CASGoogle Scholar
• 21  Duan JC, Linman MJ, Chen CY, Cheng QJ: CHCA-modified Au nanoparticles for laser desorption ionization mass spectrometric analysis of peptides. J. Am. Soc. Mass Spectrom.20(8),1530–1539 (2009).
  Medline CASGoogle Scholar
• 22  Chen LC, Mori K, Hori H, Hiraoka K: Au-assisted visible laser MALDI. Int. J. Mass Spectrom.279(1),41–46 (2009).
  CASGoogle Scholar
• 23  Chen LC, Ueda T, Sagisaka M, Hori H, Hiraoka K: Visible laser desorption/ionization mass spectrometry using gold nanorods. J. Phys.Chem. C111(6),2409–2415 (2007).
  CASGoogle Scholar
• 24  Chen LC, Yonehama J, Ueda T, Hori H, Hiraoka K: Visible-laser desorption/ionization on gold nanostructures. J. Mass Spectrom.42(3),346–353 (2007).
  Medline CASGoogle Scholar
• 25  Shan Z, Han L, Yuan MJ et al.: Mesoporous tungsten titanate as matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of biomolecules. Anal. Chim. Acta593(1),13–19 (2007).
  Medline CASGoogle Scholar
• 26  Castro AL, Madeira PJA, Nunes MR, Costa FM, Florencio MH: Titanium dioxide anatase as matrix for matrix-assisted laser desorption/ionization analysis of small molecules. Rapid Commun. Mass Spectrom.22(23),3761–3766 (2008).
  Medline CASGoogle Scholar
• 27  Chen CT, Chen YC: Molecularly imprinted TiO₂-matrix-assisted laser desorption/ionization mass spectrometry for selectively detecting α-cyclodextrin. Anal. Chem.76(5),1453–1457 (2004).
  Medline CASGoogle Scholar
• 28  Chen CT, Chen YC: Desorption/ionization mass spectrometry on nanocrystalline titania sol-gel-deposited films. Rapid Commun. Mass Spectrom.18 (17),1956–1964 (2004).
  Medline CASGoogle Scholar
• 29  Lachheb H, Puzenat E, Houas A et al.: Photocatalytic degradation of various types of dyes (alizarin S, crocein orange G, methyl red, congo red, methylene blue) in water by UV-irradiated titania. Appl. Catal. B-Environ.39(1),75–90 (2002).
  CASGoogle Scholar
• 30  Qiao L, Bi HY, Busnel JM, Liu BH, Girault HH: In-source photocatalytic reduction of disulfide bonds during laser desorption ionization. Chem. Commun. (47),6357–6359 (2008).
  MedlineGoogle Scholar
• 31  Qiao L, Bi HY, Busnel JM et al.: Photocatalytic redox reactions for in-source peptide fragmentation. Chem. Eur. J.15(27),6711–6717 (2009).▪ Peptide a,x-fragmentation during the LDI process, valuable for peptide sequencing.
  Medline CASGoogle Scholar
• 32  Qiao L, Roussel C, Wan JJ et al.: MALDI in-source photooxidation reactions for online peptide tagging. Angew. Chem. Int. Ed. Engl.47(14),2646–2648 (2008).▪ Matrix-assisted LDI (MALDI)-based on-line cysteine tagging strategy, valuable for protein accurate identification.
  Medline CASGoogle Scholar
• 33  Sunner J, Dratz E, Chen YC: Graphite surface assisted laser desorption/ionization time-of-flight mass-spectrometry of peptides and proteins from liquid solutions. Anal. Chem.67(23),4335–4342 (1995).
  Medline CASGoogle Scholar
• 34  Wen HS, Tsai LF, Liu CW et al.: Investigation of effects attributed to spherical carbon nanomaterials in proteomic matrix-assisted laser desorption ionization-time of flight mass spectrometer. 1–3, 1019–1021 (2007). Presented at: 7th IEEE Conference on Nanotechnology. Hong Kong, China, 2–5 August 2007.
  Google Scholar
• 35  Xu SY, Li YF, Zou HF, Qiu JS, Guo Z, Guo BC: Carbon nanotubes as assisted matrix for laser desorption/ionization time-of-flight mass spectrometry. Anal. Chem.75,6191–6195 (2003).
  Medline CASGoogle Scholar
• 36  Zhang J, Wang HY, Guo YL: Amino acids analysis by MALDI mass spectrometry using carbon nanotube as matrix. Chinese J. Chem.23(2),185–189 (2005).
  CASGoogle Scholar
• 37  Najam-ul-Haq M, Rainer M, Huck CW, Hausberger P, Kraushaar H, Bonn GK: Nanostructured diamond-like carbon on digital versatile disc as a matrix-free target for laser desorption/ionization mass spectrometry. Anal. Chem.80(19),7467–7472 (2008).
  Medline CASGoogle Scholar
• 38  Shenar N, Martinez J, Enjalbal C: Laser desorption/ionization mass spectrometry on porous silica and alumina for peptide mass fingerprinting. J. Am. Soc. Mass Spectrom.19(5),632–644 (2008).
  Medline CASGoogle Scholar
• 39  Watanabe T, Kawasaki H, Yonezawa T, Arakawa R: Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) of low molecular weight organic compounds and synthetic polymers using zinc oxide (ZnO) nanoparticles. J. Mass Spectrom.43(8),1063–1071 (2008).
  Medline CASGoogle Scholar
• 40  Shin WJ, Shin JH, Song JY, Han SY: Effects of ZnO nanowire length on surface-assisted laser desorption/ionization of small molecules. J. Am. Soc. Mass Spectrom.21(6),989–992 (2010)
  Medline CASGoogle Scholar
• 41  Chen ZM, Geng ZR, Shao DL, Mei YH, Wang ZL: Single-crystalline EUF3 hollow hexagonal microdisks: synthesis and application as a background-free matrix for MALDI-TOF-MS analysis of small molecules and polyethylene glycols. Anal. Chem.81(18),7625–7631 (2009).
  Medline CASGoogle Scholar
• 42  Hua L, Chen JR, Ge L, Tan SN: Silver nanoparticles as matrix for laser desorption/ionization mass spectrometry of peptides. J. Nano. Res.9,1133–1138 (2007).
  CASGoogle Scholar
• 43  Chiang CK, Yang ZS, Lin YW, Chen WT, Lin HJ, Chang HT: Detection of proteins and protein-ligand complexes using HGTE nanostructure matrixes in surface-assisted laser desorption/ionization mass spectrometry. Anal. Chem.82(11),4543–4550 (2010).
  Medline CASGoogle Scholar
• 44  Kawasaki H, Yonezawa T, Watanabe T, Arakawa R: Platinum nanoflowers for surface-assisted laser desorption/ionization mass spectrometry of biomolecules. J. Phys. Chem. C111,16278–16283 (2007).
  CASGoogle Scholar
• 45  Taira S, Kitajima K, Katayanagi H, Ichiishi E, Ichiyanagi Y: Manganese oxide nanoparticle-assisted laser desorption/ionization mass spectrometry for medical applications. Sci. Technol. Adv. Mater.10(3),034602 (2009).
  MedlineGoogle Scholar
• 46  Chen WY, Chen YC: Affinity-based mass spectrometry using magnetic iron oxide particles as the matrix and concentrating probes for SALDI MS analysis of peptides and proteins. Anal. BioAnal. Chem.386(3),699–704 (2006).
  Medline CASGoogle Scholar
• 47  Szabo Z, Vallant RM, Takatsy A et al.: Laser desorption/ionization mass spectrometric analysis of small molecules using fullerene-derivatized silica as energy-absorbing material. J. Mass Spectrom.45(5),545–552 (2010).
  Medline CASGoogle Scholar
• 48  Seino T, Sato H, Yamamoto A, Nemoto A, Torimura M, Tao H: Matrix-free laser desorption/ionization-mass spectrometry using self-assembled germanium nanodots. Anal. Chem.79(13),4827–4832 (2007).
  Medline CASGoogle Scholar
• 49  Bi HY, Girault HH: Mass spectrometry based analysis and bioanalysis. Thèse Ecole Polytechnique Fédérale de Lausanne (EPFL). Lausanne, Switzerland, No. 4741 (2010).
  Google Scholar
• 50  Chiang CK, Chiang NC, Lin ZH, Lan GY, Lin YW, Chang HT: Nanomaterial-based surface-assisted laser desorption/ionization mass spectrometry of peptides and proteins. J. Am. Soc. Mass Spectrom.21(7),1204–1207 (2010).
  Medline CASGoogle Scholar
• 51  Shenar N, Cantel S, Martinez J, Enjalbal C: Comparison of inert supports in laser desorption/ionization mass spectrometry of peptides: pencil lead, porous silica gel, DIOS-chip and NALDI target. Rapid Commun. Mass Spectrom.23(15),2371–2379 (2009).
  Medline CASGoogle Scholar
• 52  Tang HW, Ng KM, Lu W, Che CM: Ion desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: desorption mechanism(s) and the design of SALDI substrates. Anal. Chem.81(12),4720–4729 (2009).
  Medline CASGoogle Scholar
• 53  Guo Z, Ganawi AAA, Liu Q, He L: Nanomaterials in mass spectrometry ionization and prospects for biological application. Anal. Bioanal. Chem.384(3),584–592 (2006).
  Medline CASGoogle Scholar
• 54  Chiu TC, Huang LS, Lin PC et al.: Nanomaterial based affinity matrix-assisted laser desorption/ionization mass spectrometry for biomolecules and pathogenic bacteria. Recent Pat. Nanotechnol.1(2),99–111 (2007).
  Medline CASGoogle Scholar
• 55  Vidova V, Novak P, Strohalm M, Pol J, Havlicek V, Volny M: Laser desorption-ionization of lipid transfers: tissue mass spectrometry imaging without MALDI matrix. Anal. Chem.82(12),4994–4997 (2010).▪ A very interesting LDI-mass spectrometry (MS) imaging strategy, where the nanomaterial-assisted LDI (NALDI) plate was firstly used as a substrate for the imprinting of tissue section for MS imaging.
  Medline CASGoogle Scholar
• 56  Kraj A, Dylag T, Gorecka-Drzazga A, Bargiel S, Dziuban J, Silberring J: Desorption/ionization on silicon for small molecules: a promising alternative to MALDI TOF. Acta Biochimica Polonica50(3),783–787 (2003).
  Medline CASGoogle Scholar
• 57  Budimir N, Blais JC, Fournier F, Tabet JC: Desorption/ionization on porous silicon mass spectrometry (DIOS) of model cationized fatty acids. J. Mass Spectrom.42(1),42–48 (2007).
  Medline CASGoogle Scholar
• 58  Budimir N, Blais JC, Fournier F, Tabet JC: The use of desorption/ionization on porous silicon mass spectrometry for the detection of negative ions for fatty acids. Rapid Commun. Mass Spectrom.20(4),680–684 (2006).
  Medline CASGoogle Scholar
• 59  Wen XJ, Dagan S, Wysocki VH: Small-molecule analysis with silicon-nanoparticle-assisted laser desorption/ionization mass spectrometry. Anal. Chem.79(2),434–444 (2007).
  Medline CASGoogle Scholar
• 60  Kraj A, Jarzebinska J, Gorecka-Drzazga A, Dziuban J, Silberring J: Identification of catecholamines in the immune system by desorption/ionization on silicon. Rapid Commun. Mass Spectrom.20(13),1969–1972 (2006).
  Medline CASGoogle Scholar
• 61  Arakawa R, Shimomae Y, Morikawa H, Ohara K, Okuno S: Mass spectrometric analysis of low molecular mass polyesters by laser desorption/ionization on porous silicon. J. Mass Spectrom.39(8),961–965 (2004).
  Medline CASGoogle Scholar
• 62  Okunoa S, Wada Y, Arakawa R: Quantitative analysis of polypropyleneglycol mixtures by desorption/ionization on porous silicon mass spectrometry. Int. J. Mass Spectrom.241(1),43–48 (2005).
  Google Scholar
• 63  Go EP, Shen ZX, Harris K, Siuzdak G: Quantitative analysis with desorption/ionization on silicon mass spectrometry using electrospray deposition. Anal. Chem.75(20),5475–5479 (2003).
  Medline CASGoogle Scholar
• 64  Wall DB, Finch JW, Cohen SA: Quantification of codeine by desorption/ionization on silicon time-of-flight mass spectrometry and comparisons with liquid chromatography/mass spectrometry. Rapid Commun. Mass Spectrom.18(12),1403–1406 (2004).
  CASGoogle Scholar
• 65  Pan CS, Xu SY, Hu LG et al.: Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS. J. Am. Soc. Mass Spectrom.16(6),883–892 (2005).
  Medline CASGoogle Scholar
• 66  Lo CY, Lin JY, Chen WY, Chen CT, Chen YC: Surface-assisted laser desorption/ionization mass spectrometry on titania nanotube arrays. J. Am. Soc. Mass Spectrom.19(7),1014–1020 (2008).
  Medline CASGoogle Scholar
• 67  Su CL, Tseng WL: Gold nanoparticles as assisted matrix for determining neutral small carbohydrates through laser desorption/ionization time-of-flight mass spectrometry. Anal. Chem.79(4),1626–1633 (2007).
  Medline CASGoogle Scholar
• 68  Shen ZX, Go EP, Gamez A et al.: A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a desorption/ionization on silicon (DIOS) platform. Chembiochem.5(7),921–927 (2004).
  Medline CASGoogle Scholar
• 69  Thomas JJ, Shen ZX, Crowell JE, Finn MG, Siuzdak G: Desorption/ionization on silicon (DIOS): a diverse mass spectrometry platform for protein characterization. Proc. Natl Acad. Sci. USA98(9),4932–4937 (2001).▪▪ LDI-based enzyme activity investigation with high throughput and efficiency.
  Medline CASGoogle Scholar
• 70  Li Q, Ricardo A, Benner SA, Winefordner JD, Powell DH: Desorption/ionization on porous silicon mass spectrometry studies on pentose-borate complexes. Anal. Chem.77(14),4503–4508 (2005).▪▪ DIOS-MS as an ideal platform for the investigation of reaction equilibrium.
  Medline CASGoogle Scholar
• 71  van Hove ERA, Smith DF, Heeren RMA: A concise review of mass spectrometry imaging. J. Chromatogr. A1217(25),3946–3954 (2010).
  MedlineGoogle Scholar
• 72  Chughtai K, Heeren RMA: Mass spectrometric imaging for biomedical tissue analysis. Chem. Rev.110(5),3237–3277 (2010).
  Medline CASGoogle Scholar
• 73  McDonnell LA, Heeren RMA: Imaging mass spectrometry. Mass Spectrom. Rev.26(4),606–643 (2007).
  Medline CASGoogle Scholar
• 74  Liu Q, Guo Z, He L: Mass spectrometry imaging of small molecules using desorption/ionization on silicon. Anal. Chem.79(10),3535–3541 (2007).
  Medline CASGoogle Scholar
• 75  Ageta H, Asai S, Sugiura Y, Goto-Inoue N, Zaima N, Setou M: Layer-specific sulfatide localization in rat hippocampus middle molecular layer is revealed by nanoparticle-assisted laser desorption/ionization imaging mass spectrometry. Med. Mol. Morphol.42(1),16–23 (2009).
  Medline CASGoogle Scholar
• 76  Taira S, Sugiura Y, Moritake S, Shimma S, Ichiyanagi Y, Setou M: Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution. Anal. Chem.80(12),4761–4766 (2008).
  Medline CASGoogle Scholar
• 77  Wan JJ, Qian K, Qiao L et al.: TiO₂-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides. Chem. Eur. J.15(11),2504–2508 (2009).
  Medline CASGoogle Scholar
• 78  Blacken GR, Volny M, Vaisar T, Sadilek M, Turecek F: In situ enrichment of phosphopeptides on MALDI plates functionalized by reactive landing of zirconium(IV)-N-propoxide ions. Anal. Chem.79(14),5449–5456 (2007).
  Medline CASGoogle Scholar
• 79  Bi HY, Qiao L, Busnel JM, Devaud V, Liu BH, Girault HH: TiO₂ printed aluminum foil: single-use film for a laser desorption/ionization target plate. Anal. Chem.81(3),1177–1183 (2009).
  Medline CASGoogle Scholar
• 80  Qiao L, Roussel C, Wan JJ, Yang PY, Girault HH, Liu BH: Specific on-plate enrichment of phosphorylated peptides for direct MALDI-TOF MS analysis. J. Proteome Res.6(12),4763–4769 (2007).
  Medline CASGoogle Scholar
• 81  Qiao LA, Bi HY, Busnel JM et al.: Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry. Chem. Sci.1(3),374–382 (2010).
  CASGoogle Scholar
• 82  Lee KH, Chiang CK, Lin ZH, Chang HT: Determining enediol compounds in tea using surface-assisted laser desorption/ionization mass spectrometry with titanium dioxide nanoparticle matrices. Rapid Commun. Mass Spectrom.21(13),2023–2030 (2007).
  Medline CASGoogle Scholar
• 83  Huang YF, Chang HT: Nile red-adsorbed gold nanoparticle matrixes for determining aminothiols through surface-assisted laser desorption/ionization mass spectrometry. Anal. Chem.78(5),1485–1493 (2006).
  Medline CASGoogle Scholar
• 84  Huang YF, Chang HT: Analysis of adenosine triphosphate and glutathione through gold nanoparticles assisted laser desorption/ionization mass spectrometry. Anal. Chem.79(13),4852–4859 (2007).
  Medline CASGoogle Scholar
• 85  Kim YP, Oh E, Oh YH, Moon DW, Lee TG, Kim HS: Protein kinase assay on peptide-conjugated gold nanoparticles by using secondary-ion mass spectrometric imaging. Angew. Chem. Int. Ed. Engl.46,6816–6819 (2007).
  Medline CASGoogle Scholar
• 86  Nagahori N, Nishimura SI: Direct and efficient monitoring of glycosyltransferase reactions on gold colloidal nanoparticles by using mass spectrometry. Chem. Eur. J.12(25),6478–6485 (2006).
  Medline CASGoogle Scholar
• 87  Qiu F, Jiang DW, Ding YB, Zhu J, Huang LL: Monolayer-barcoded nanoparticles for on-chip DNA hybridization assay. Angew. Chem. Int. Ed. Engl.47(27),5009–5012 (2008).▪ MS-based signal amplification method for DNA hybridization investigation.
  Medline CASGoogle Scholar
• 88  Lee JR, Lee A, Kim SK, Kim KP, Park HS, Yeo WS: Mass spectrometry signal amplification method for attomolar detection of antigens using small-molecule-tagged gold microparticles. Angew. Chem. Int. Ed. Engl.47(49),9518–9521 (2008).
  Medline CASGoogle Scholar
• 89  Zhu ZJ, Ghosh PS, Miranda OR, Vachet RW, Rotello VM: Multiplexed screening of cellular uptake of gold nanoparticles using laser desorption/ionization mass spectrometry. J. Am.Chem. Soc.130(43),14139–14143 (2008).▪ Analysis of cellular uptake of nanoparticles based on MS.
  Medline CASGoogle Scholar
• 90  Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol.39(1),44–84 (2007).
  Medline CASGoogle Scholar
• 91  Okuno S, Arakawa R, Wada Y: Reduction of Cu(II) and riboflavin in DIOS mass spectrometry. J. Mass Spectrom. Soc. Jpn.52(1),13–20 (2004).
  CASGoogle Scholar
• 92  Okuno S, Nakano M, Matsubayashi G, Arakawa R, Wada Y: Reduction of organic dyes in matrix-assisted laser desorption/ionization and desorption/ionization on porous silicon. Rapid Commun. Mass Spectrom.18(23),2811–2817 (2004).
  Medline CASGoogle Scholar
• 93  Okuno S, Oka K, Arakawa R: Oxidation of ferrocene derivatives in desorption/ionization on porous silicon. Anal. Sci.21(12),1449–1451 (2005).
  Medline CASGoogle Scholar
• 94  Finkel T, Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Nature408(6809),239–247 (2000).
  Medline CASGoogle Scholar
• 95  Bi HY, Qiao L, Busnel JM, Liu BH, Girault HH: Kinetics of proteolytic reactions in nanoporous materials. J. Proteome Res.8(10),4685–4692 (2009).
  Medline CASGoogle Scholar
• 96  Qiao L, Liu Y, Hudson SP, Yang PY, Magner E, Liu BH: A nanoporous reactor for efficient proteolysis. Chem. Eur. J.14(1),151–157 (2008).
  Medline CASGoogle Scholar
• 97  Qian K, Wan JJ, Qiao L et al.: Macroporous materials as novel catalysts for efficient and controllable proteolysis. Anal. Chem.81(14),5749–5756 (2009).
  Medline CASGoogle Scholar
• 98  Abonnenc M, Qiao LA, Liu BH, Girault HH: Electrochemical aspects of electrospray and laser desorption/ionization for mass spectrometry. Ann. Rev. Anal. Chem.3,231–254 (2010).
  Medline CASGoogle Scholar
• 99  Girault H, Liu BH, Qiao LA et al.: Electrochemical reactions and ionization processes. Euro. J. Mass Spectrom.16(3),341–349 (2010).
  Medline CASGoogle Scholar