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Research Article

Nanoparticle–dendrimer hybrid nanocapsules for therapeutic delivery

    Youngdo Jeong‡

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

    ‡Authors contributed equally

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    ,
    Sung Tae Kim‡

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

    ‡Authors contributed equally

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    ,
    Ying Jiang

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Bradley Duncan

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Chang Soo Kim

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Krishnendu Saha

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Yi-Cheun Yeh

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Bo Yan

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Rui Tang

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Singyuk Hou

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Chaekyu Kim

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    ,
    Myoung-Hwan Park

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

    Department of Chemistry, Sahmyook University, Seoul 139-742, South Korea

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    &
    Vincent M Rotello

    *Author for correspondence:

    E-mail Address: rotello@chem.umass.edu

    Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA

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    Published Online:13 May 2016https://doi.org/10.2217/nnm-2016-0034

    Abstract

    Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy.

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