Special Report

Laboratoire MCMP, UMR 5234 CNRS-Université de Bordeaux Victor Segalen, 146 rue Léo Saignat, 33076 Bordeaux cedex, France

Institut Pasteur, UMR 3015 CNRS, 25 rue du Dr Roux, 75724 Paris cedex 15, France

Laboratoire Joliot-Curie, USR3010, ENS de Lyon, 46, allée d’Italie 69364, Lyon, France

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Vincent Parissi

† Author for correspondence

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Email the corresponding author at vincent.parissi@reger.u-bordeaux2.fr

Published Online:15 Sep 2011https://doi.org/10.2217/fvl.11.84

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Abstract

Human AIDS, owing to HIV-1, remains a major health issue despite the numerous antiviral compounds that are now available. One of the main obstacles for these antiviral strategies is the appearance of highly resistant viral strains, making the search for new antiviral targets a crucial issue. The insertion of the viral genome into the cell chromosomal DNA, catalyzed by the retroviral integrase enzyme, is required for stable infection and thus constitutes a suitable target for the antiretroviral molecules currently used in therapy. The precise mechanism of interaction between the integration complex (intasome) and the target chromatin remains poorly understood, thus restricting the development of new therapeutic strategies and original methods to control gene transfer in gene therapy. In this article, we summarize the data obtained in this field and underline recent results highlighting this process and paving the way for new and more detailed understanding of this mechanism.

Keywords:

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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Published online 15 September 2011

Published in print September 2011

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The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

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HIV-1 integration into chromatin: new insights and future perspectives

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