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EditorialFree Access

Blood gene-expression profiling for preonset identification of multiple sclerosis

    Anat Achiron

    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel and Sackler School of Medicine, Tel Aviv University, Israel.

    Published Online:https://doi.org/10.2217/fnl.10.43
    Free first page

    Bibliography

    • Weiner HL: A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J. Neurol.255(Suppl. 1),3–11 (2008).
    • Lassmann H: Multiple sclerosis: is there neurodegeneration independent from inflammation? J. Neurol. Sci.259,3–6 (2007).
    • Collins CD, Purohit S, Podolsky RH et al.: The application of genomic and proteomic technologies in predictive, preventive and personalized medicine. Vascul. Pharmacol.45,258–267 (2006).
    • Achiron A, Gurevich M, Friedman N, Kaminski N, Mandel M: Blood transcriptional signature of multiple sclerosis: unique gene expression of disease activity. Ann. Neurol.55,410–417 (2004).
    • Achiron A, Feldman A, Mandel M, Gurevich M: Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Ann. NY Acad. Sci.1107,155–167 (2007).
    • Achiron A, Gurevich M, Snir Y, Segal E, Mandel M: Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing–remitting multiple sclerosis. Clin. Exp. Immunol.149,235–422 (2007).
    • Gurevich M, Tuller T, Rubinstein U, Or-Bach R, Achiron A: Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells. BMC Med. Genomics2,46 (2009).
    • Achiron A, Grotto I, Balicer R, Magalashvili D, Feldman A, Gurevich M: Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis. Neurobiol. Dis.38,201–209 (2010).
    • Bischof F, Bins A, Dürr M, Zevering Y, Melms A, Kruisbeek AM: A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response. J. Immunol.173,600–606 (2004).
    • 10  Deng X, Ljunggren-Rose A, Maas K, Sriram S: Defective ATM-p53-mediated apoptotic pathway in multiple sclerosis. Ann. Neurol.58,577–584 (2005).
    • 11  Sharief MK, Douglas M, Noori M, Semra YK: The expression of pro- and anti-apoptosis Bcl-2 family proteins in lymphocytes from patients with multiple sclerosis. J. Neuroimmunol.125,155–162 (2002).
    • 12  Saresella M, Marventano I, Speciale L et al.: Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis. J. Neuroimmunol.166,173–179 (2005).