Special Focus: Nanoparticles for Cancer Diagnosis & Therapeutics - Review

Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy

Georgia Institute of Technology, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.

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Email the corresponding author at melsayed@gatech.edu

Prashant K Jain

Georgia Institute of Technology, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.

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Email the corresponding author at melsayed@gatech.edu

Ivan H El-Sayed

Georgia Institute of Technology, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.

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Email the corresponding author at melsayed@gatech.edu

Mostafa A El-Sayed

† Author for correspondence

Georgia Institute of Technology, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Atlanta, GA 30332, USA.

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Email the corresponding author at melsayed@gatech.edu

Published Online:2 Nov 2007https://doi.org/10.2217/17435889.2.5.681

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Abstract

Recent years have seen tremendous progress in the design and study of nanomaterials geared towards biological and biomedical applications, most notable among these being the noble metal nanoparticles. In this review, we outline the surface-plasmon resonance-enhanced optical properties of colloidal gold nanoparticles directed towards recent biomedical applications with an emphasis on cancer diagnostics and therapeutics. Methods of molecular-specific diagnostics/detection of cancer, including strongly enhanced surface plasmon resonance light-scattering, surface-enhanced emission of gold nanorods and surface-enhanced Raman scattering, are described. We also discuss the plasmonic photothermal therapy of cancer achieved by using the strongly enhanced surface-plasmon resonance absorption of gold nanospheres and nanorods.

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Vol. 2, No. 5

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Published online 2 November 2007

Published in print October 2007

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Financial & competing interests disclosure

We thank the financial support of the NCI Center of Cancer Nanotechnology Excellence (CCNE) Award (U54CA119338). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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